Localized pemphigus herpetiformis: two case reports
نویسندگان
چکیده
Pemphigus herpetiformis (PHF) is a rare variant of pemphigus that combines the clinical features of dermatitis herpetiformis and immunopathological features of pemphigus. In previous case reports, distribution of lesions is usually generalized, involving trunk and limbs. We report two cases of localized PHF presenting with grouped pustules on bilateral dorsal feet and left preauricular area, respectively. Microscopic examination showed neutrophilic spongiosis, subcorneal pustules, and focal acantholysis. Both direct immunofluorescence of Case 1 and indirect immunofluorescence of Case 2 revealed moderate deposition of IgG in the intercellular space of upper epidermis. Based on the typical histologic features and immunopathological findings, diagnoses of PHF were made. However, the atypical and localized clinical presentation rendered the process of reaching a diagnosis more difficult. PHF should be added in the spectrum of differential diagnosis of localized pustular disorders. Copyright © 2010, Taiwanese Dermatological Association. Published by Elsevier Taiwan LLC. All rights reserved.
منابع مشابه
Concomitant pemphigus herpetiformis and sarcoidosis
Dsg: desmoglein H&E: hematoxylin-eosin IL: interleukin PH: pemphigus herpetiformis INTRODUCTION Pemphigus herpetiformis (PH) is a rare variant of pemphigus and accounts for approximately 7% of cases. PH combines the clinical features of dermatitis herpetiformis with the histologic features of pemphigus. Clinically, the plaques are herpetiform or even annular. PH follows a more benign course wit...
متن کاملNon-classical forms of pemphigus: pemphigus herpetiformis, IgA pemphigus, paraneoplastic pemphigus and IgG/IgA pemphigus*
The pemphigus group comprises the autoimmune intraepidermal blistering diseases classically divided into two major types: pemphigus vulgaris and pemphigus foliaceous. Pemphigus herpetiformis, IgA pemphigus, paraneoplastic pemphigus and IgG/IgA pemphigus are rarer forms that present some clinical, histological and immunopathological characteristics that are different from the classical types. Th...
متن کاملThe importance of direct immunofluorescence in pemphigus herpetiformis diagnosis*
Pemphigus herpetiformis is an autoimmune bullous disease, that combines clinical features of dermatitis herpetiformis and linear IgA bullous dermatosis and immunological characteristics of pemphigus, which makes this disease peculiar and this diagnosis rarely suspected in the first evaluation of the patient. The reported case is of a patient with clinically bullous disease similar to dermatitis...
متن کاملA Case of Pemphigus Herpetiformis in a 12-Year-Old Male
Pemphigus herpetiformis (PH) is one of the less common forms of pemphigus. PH in children is unreported. We describe a case of a child who developed PH. Observation. A 12-year-old boy was seen at our department with erosive plaques, vesicles, and crusted cutaneous lesions associated with severe itching persisting for six months. Histologic examination showed an intraepidermal bulla containing r...
متن کاملLocalized pemphigus foliaceus with unilateral facial involvement: A case report
Pemphigus foliaceus is an autoimmune blistering condition more often than not associated with generalized lesions. Localized Pemphigus foliaceus is a rare entity. Herein, we report a case of pemphigus foliaceus localized on the face. A 64-year-old woman was referred to our clinic with a 2-year history of erythematous plaque on the right side of her face. The histology report was compatible with...
متن کامل